Polycythemia Vera and other Myeloproliferative neoplasms (MPN)

Polycythemia Vera and other Myeloproliferative neoplasms (MPN)

What is Polycythemia Vera and other Myeloproliferative neoplasms (MPN)

Polycythemia vera (PV) is a chronic blood cancer that's part of a group of conditions called myeloproliferative neoplasms (MPNs). MPNs are characterized by an abnormal expansion of hematopoietic stem cells.

Symptoms

• Thickened blood
• Itchy skin, especially after a hot shower or bath
• Fatigue
• Fevers
• Weight loss
• Night sweats

Complications

• Bleeding problems
• Blood clots in blood vessels, which can lead to stroke or heart attack
• Swollen spleen
• Increased risk of acute myeloid leukemia or primary myelofibrosis

Treatment

• Treatment for MPNs aims to control symptoms.
• Aspirin and phlebotomy may help reduce symptoms in low-risk patients.
• Hydroxyurea is a drug that can reduce blood counts and the risk of thrombosis.
• Hematopoietic stem cell transplants are another treatment option, but they have significant complications.